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Istradefylline forty mg/working day increased peak concentrations and AUC of CYP3A4 substrates in scientific trials. This result was not noticed with istradefylline 20 mg/day. Think about dose reduction of delicate CYP3A4 substrates.darifenacin will improve the amount or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.